MR appearance of autologous chondrocyte implantation in the knee: correlation with the knee features and clinical outcome.

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文献标题：: MR appearance of autologous chondrocyte implantation in the knee: correlation with the knee features and clinical outcome.

参考中文标题：: MR表现的自体软骨细胞植入膝盖：与膝关节功能和临床疗效。

文献摘要：: OBJECTIVE: To relate the magnetic resonance imaging (MRI) appearance of autologous chondrocyte implantation (ACI) in the knee in the 1st postoperative year with other knee features on MRI and with clinical outcome. DESIGN AND METHODS: Forty-nine examinations were performed in 49 patients at 1 year after ACI in the knee. Forty-one preoperative magnetic resonance (MR) examinations were also available. The grafts were assessed for smoothness, thickness in comparison with that of adjacent cartilage, signal intensity, integration to underlying bone and adjacent cartilage, and congruity of subchondral bone. Presence of overgrowth and bone marrow appearance beneath the graft were also assessed. Presence of osteophyte formation, further cartilage defects, appearance of the cruciate ligaments and the menisci were also recorded. An overall graft score was constructed, using the graft appearances. This was correlated with the knee features and the Lysholm score, a clinical self-assessment score. The data were analysed by a Kruskal-Wallis H test followed by a Mann-Whitney U test with Bonferroni correction as post-hoc test. RESULTS: Of 49 grafts, 32 (65%) demonstrated complete defect filling 1 year postoperatively. General overgrowth was seen in eight grafts (16%), and partial overgrowth in 13 grafts (26%). Bone marrow change underneath the graft was seen; oedema was seen in 23 grafts (47%), cysts in six grafts (12%) and sclerosis in two grafts (4%). Mean graft score was 8.7 (of maximal 12) (95% CI 8.0-9.5). Knees without osteophyte formation or additional other cartilage defects (other than the graft site) had a significantly higher graft score than knees with multiple osteophytes (P=0.0057) or multiple further cartilage defects (P=0.014). At 1 year follow-up improvement in the clinical scores was not significantly different for any subgroup. Knees with a graft score of 8 points or greater had a better improvement of the clinical score than those of 7 points or fewer. CONCLUSIONS: At 1 year follow-up after ACI, higher graft scores are associated with an overall better preserved knee joint. ACI improves the clinical outcome, but there is no statistically significant correlation of graft score and clinical outcome.

参考中文摘要：: 目的：涉及的磁共振成像（ MRI ）出现自体软骨细胞移植（脑梗死）在膝部手术后的第1年与其他膝关节功能磁共振成像与临床结果。设计和方法： 49个考试进行了49例在1年后脑梗塞的膝盖。 41个术前磁共振（先生）考试也可以。移植被分摊的光滑，厚度相比，与邻近的软骨，信号强度，一体化的基本骨骼和邻近软骨和一致性的软骨。存在过度和骨髓移植的外观下面还评估。在场的骨赘形成，进一步软骨缺损，外观十字韧带和半月板亦录。整体移植评分建造，使用移植露面。这是与膝关节功能和Lysholm评分，临床自我评估评分。这些数据进行分析的非参数检验H测试之后，以Mann - Whitney U检验与Bonferroni校正后的临时检验。结果： 49例， 32 （ 65 ％）表现出完整的缺陷填补，术后1年。一般过度，看到在8移植（ 16 ％），并在13个部分过度移植（ 26 ％）。骨髓移植改变底下看到;水肿被认为在23移植（ 47 ％），囊肿6例（ 12 ％）和硬化两个移植（ 4 ％）。平均移植评分为8.7 （最大12 ）（ 95 ％ CI为8.0-9.5 ）。膝盖没有骨赘形成或增加其他软骨缺损（除移植网站）有一个显着高于移植评分超过膝盖与多个osteophytes （ P值0.0057 ）或多个进一步软骨缺损（ P值0.014 ）。在一年的后续改善临床分数无显着差异的任何分组。膝盖与移植评分为8分或更高了一个更好的改善临床评分比7分或更少。结论：在1年后的后续行动脑梗死，高移植分数都与整体更好的保存膝关节。脑梗死提高临床疗效，但没有统计学意义的相关性移植物抗评分和临床疗效。

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作者单位：: Department of Radiology & Institute of Orthopaedics, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Oswestry, Shropshire, UK.

文献来源：: Skeletal Radiology. 35(1):16-26, 2006 Jan.

NLM刊名：: Skeletal radiology 浏览此刊所有文献

出版国家：: Germany

所用语言：: English

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PMID及链接：: 16284767 http://www.syyxw.com/Archive/Detail/16284767