设为首页 | 收藏本站
文献信息详细页面
- 文献标题：
- Tumor necrosis in osteosarcoma: inclusion of the point of greatest metabolic activity from F-18 FDG PET/CT in the histopathologic analysis.
- 参考中文标题：
- 肿瘤坏死骨肉瘤：最大的代谢活动从F点列入- 18 FDG PET显像/病理分析中的CT。
- 文献摘要：
- OBJECTIVE: To determine if the location of the point of maximum standardized uptake value (SUVmax) being included in or not included in the histopathologic slab section corresponded to tumor necrosis or survival. MATERIALS AND METHODS: Twenty-nine osteosarcoma patients underwent post-chemotherapy [fluorine-18]-fluoro-2-deoxy-D: -glucose (FDG) positron-emission tomography-computed tomography (PET/CT) prior to resection. PET/CT images were correlated with slab-section location as determined by photographs or knowledge of specimen processing. The location of the point of SUVmax was then assigned as being 'in' or 'out' of the slab section. Cox's proportional hazard regression was used to evaluate relationships between the location and value of SUVmax and survival. Logistic regression was employed to evaluate tumor necrosis. RESULTS: No correlation was found between the SUVmax location and survival or tumor necrosis. High SUVmax correlated to poor survival. CONCLUSION: High SUVmax value correlated to poor survival. Minimal viable tumor (> 10%) following chemotherapy is a known indicator of poor survival. No correlation was found between the location of SUVmax and survival or tumor necrosis. Therefore, the SUVmax value either does not correspond to a sufficient number of tumor cells to influence tumor necrosis measurement or it was included in the out-of-slab samples that were directed to viable-appearing areas of the gross specimen. Since high SUVmax has been previously found to correspond to poor tumor necrosis, and tumor necrosis is simply an estimate of the amount of viable tumor, SUVmax likely represents many viable tumor cells. Therefore, when not in the slab section, SUVmax was likely included in the tumor necrosis measurement through directed sampling, validating our current method of osteosarcoma specimen analysis.
- 参考中文摘要：
- 目的：确定的最高标准摄取值（SUVmax）点的位置正在或不包括在病理平板节中包含对应的肿瘤坏死或生存。材料与方法：29位后的骨肉瘤患者接受化疗[氟- 18]氟- 2 -脱氧- D：-葡萄糖（葡萄糖）正电子发射断层扫描型计算机断层扫描（PET / CT）的前切除。 PET / CT的图像相关的平板节由照片或样品加工知识确定位置。该点的位置的SUVmax当时在被指定为''或'走出板区段。考克斯的比例风险回归分析评价之间的位置和SUVmax和生存价值的关系。 Logistic回归是用来评估肿瘤坏死。结果：无相关关系的SUVmax位置和生存或肿瘤坏死找到。高SUVmax相关，穷人的生存。结论：高SUVmax价值相关，穷人的生存。最低可存活肿瘤（“10％），化疗后，穷困的生存已知的指标。无明显相关性之间SUVmax和生存或肿瘤坏死的位置。因此，SUVmax价值或者不符合肿瘤细胞的足够数量影响肿瘤坏死测量或它的失去了板式样品都是针对出现的可行的大体标本领域包括在内。由于高SUVmax以前已发现符合贫困肿瘤坏死，肿瘤坏死只是一个可行的肿瘤数量的估计，SUVmax可能代表了许多可行的肿瘤细胞。因此，没有在平板节，SUVmax很可能包括在通过针对肿瘤坏死抽样测量，证明我们的骨肉瘤标本分析，目前的方法。
- 文献作者：
- 暂不显示,提交全文请求后在论坛显示
- 作者单位：
- Division of Diagnostic Imaging, Department of Radiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1273, Houston, TX 77030, USA. ccostelloe@mdanderson.org
- 文献来源：
- Skeletal radiology. 39(2):131-40, 2010 Feb.
- NLM刊名：
- Skeletal radiology 浏览此刊所有文献
- 出版国家：
- Germany
- 所用语言：
- eng
- 全文链接：
- 点击查看
- 中文提供：
-
- 求助全文：
- 绿色通道(应助快,成功概率高) 求助参考文献信息 求助引文信息
- 求助翻译：
- 求助文摘人工翻译(10医币以下会员每天限1篇，违则禁止求助)
- 相关链接：
- medline pubmed Google Scholar
- 国内馆藏：
（需要消耗1医币）
- 国际馆藏：
-
- PMID及链接：
- 19760279 http://www.syyxw.com/Archive/Detail/19760279
关于我们 | 下载中心 | 欢迎加盟 | 联系我们 | 投诉建议 | 常见问题 | 网站地图
Copyright © 2010 双语医学网版权所有
