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1
参考中文标题:
术前化疗治疗软组织肉瘤:重新发明轮子。
PMID及链接:
18488216 http://www.syyxw.com/Archive/Detail/18488216
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2
参考中文标题:
应用干细胞在骨修复。
PMID及链接:
18193216 http://www.syyxw.com/Archive/Detail/18193216
摘 要:
Bone has the ability to repair minor injuries through remodeling. However, when the host source of osteoprogenitors is compromised at the defect site, one effective treatment may be cell-based therapy, as it replenishes the area of bone loss with cells possessing osteogenic potential. This review is a concise comparison of different types of stem cells that have the potential to be used in tissue-engineered scaffolds for bone repair. The clinical use of mesenchymal stem or stromal cells isolated from the bone marrow for treating various diseases has been well documented. However, the scarcity of these cells prompts the search for alternative sources of multipotential cells such as amniotic fluid stem cells and umbilical cord perivascular cells. Embryonic stem cells are another controversial source of cells with osteogenic potential. These cells have the ability to differentiate into all cell types of the adult body. Issues such as the use of human embryos and the risk of contamination from animal-derived culture components continue to prevent the therapeutic use of ESCs. As a result, abundant research has been carried out to design defined culture conditions for culturing ESCs, and alternative strategies such as the generation of induced pluripotent stem cells are being developed to eliminate the need for using embryos for cell derivation. In addition to the cell source, the ability to control stem cell differentiation into functional bone and the choice of biomaterial are also paramount objectives that are being examined in research and clinical trials.
参考中文摘要:
骨有能力修复轻伤通过重塑。然而,当东道国来源osteoprogenitors受到损害的缺陷的网站,一个有效的治疗方法可能是基于细胞的治疗,因为这方面的补充骨丢失与细胞具有成骨能力。这项审查是一个简明的比较不同类型的干细胞有可能被用于组织工程骨修复支架。临床应用的间质干或基质细胞分离出骨髓治疗各种疾病一直都有详细记载。然而,缺乏这些细胞提示寻找替代资金来源多能细胞,如羊水干细胞和脐带周围细胞。胚胎干细胞是另一个有争议的细胞来源的成骨潜能。这些细胞有能力分化成所有类型细胞的成年人身体。问题,如使用人类胚胎和污染的风险来自动物性文化的组成部分继续治疗,以防止使用胚胎。其结果是,大量的研究已进行了设计规定的培养条件下培养胚胎,以及替代战略,如新一代的诱导多能性干细胞,还开发了无需使用胚胎细胞推导。此外,细胞来源的能力,控制干细胞分化成骨功能和生物材料的选择也是至关重要的目标,正在审议中的研究和临床试验。
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3
参考中文标题:
骨髓水肿在膝关节骨关节病和与全膝关节置换术在一项为期三年的后续行动。
PMID及链接:
18463865 http://www.syyxw.com/Archive/Detail/18463865
摘 要:
OBJECTIVE: The purpose of this study was to determine if a correlation exists between magnetic resonance imaging (MRI) findings of bone marrow edema (BME) in osteoarthrosis (OA) of the knee joint and need for total knee arthroplasty (TKA) within a follow-up period of 3 years. MATERIALS AND METHODS: The entire database of knee MR studies over a 3-year period was used to select individuals with knee OA. A chart review was conducted to identify and include only those who had a 3-year follow-up appointment from the time of the initial MR study. There were 25 patients in the OA-only group (four men and 21 women; age range, 28-75; average age, 49.3 years). The OA and BME group had 48 patients (23 men and 25 women; average age, 55.5 years). The MRs were reviewed and interpreted by a musculoskeletal radiologist and were classified into one of four patterns of BME: none, focal, global, or cystic pattern. Meniscal tear and degree of cartilage loss were also assessed. RESULTS: Subjects who had BME of any pattern type were 8.95 times as likely to progress rapidly to a TKA when compared to subjects with no BME (p = 0.016). Subjects with a global pattern of BME were 5.45 times as likely to have a TKA compared to subjects with focal, cyst, or no BME (p < 0.05). Subjects with a global edema pattern were 13.04 times as likely to have a TKA than subjects with no marrow edema in the knee (p < 0.01). There was no correlation of TKA with meniscal tear or cartilage loss. The group of subjects who had a TKA were 12.6 years older than those who did not have a TKA (p < 0.001). However, the BME results were still significant after accounting for the age difference. CONCLUSION: Our classification of patterns into global, focal, cystic, and absence of BME is an attempt to further define edema in osteoarthrosis and how it relates to clinical progression. Patients with BME and OA have an increased risk of TKA as opposed to OA and no marrow edema. The BME pattern with the worst prognosis for the knee is the global pattern.
参考中文摘要:
目的:本研究以确定是否存在着相关性磁共振成像( MRI )结果骨髓水肿(生物医学工程)在骨关节病(办公自动化)膝关节和需要全膝关节置换术(激肽释放酶)在后续期为3年。材料与方法:整个数据库的膝关节磁共振研究了3年期间用于选择个人膝关节炎。图表进行审查,以查明和只包括谁了3年随访任命的时候,最初的磁共振研究。有25例在办公自动化系统,不仅集团( 4名男子和21名妇女,年龄范围28-75 ;平均年龄, 49.3岁) 。办公自动化和生物医学工程组48例( 23名男子和25名妇女,平均年龄55.5岁) 。该抄表员进行了审查,并解释了肌肉骨骼放射和被分为四个模式,生物医学工程: 0票,协调,全球性的,或囊性模式。半月板撕裂和损失程度的软骨也评估。结果:谁在生物医学工程学科的任何模式类型的8.95倍,可能会进展迅速向激肽释放酶相比,没有任何生物医学工程学科( p值= 0.016 ) 。科目与全球模式生物医学工程是5.45倍,有可能对激肽释放酶相比,科目与联络,囊肿,或根本没有生物医学工程( p “ 0.05 ) 。科目全球水肿模式是13.04倍,有可能对激肽释放酶科目,没有比骨髓水肿的膝盖( p “ 0.01 ) 。无相关的激肽释放酶与半月板撕裂或软骨损失。该组的主题谁的激肽释放酶是一十二点六年以上这些谁没有激肽释放酶( p “ 0.001 ) 。然而,生物医学工程的结果仍然是重大的会计后的年龄差异。结论:我们的分类模式纳入全球,协调,囊性,并没有生物医学工程是试图进一步界定水肿骨关节病以及它如何与临床进展。患者有生物医学工程和办公自动化的风险增加激肽释放酶,而不是OA和无骨髓水肿。在生物医学工程模式与预后最差的膝盖是全球格局。
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4
参考中文标题:
变化对磁共振断层扫描在膝关节的马拉松运动员: 10年的纵向研究。
PMID及链接:
18483739 http://www.syyxw.com/Archive/Detail/18483739
摘 要:
OBJECTIVE: The aim of the study was to evaluate long-term damage in the internal structures of the knee joints of recreational long-distance runners. MATERIALS AND METHODS: Ten years after their participation in a baseline study concerning their knee joints, seven long-distance runners and one who had given up long-distance running were invited to participate in a repeat magnetic resonance imaging (MRI) investigation. The same evaluation criteria and the same technical equipment were used, and the results of the two investigations were compared. RESULT: No adverse long-term consequences were observed in six of the seven active runners, regardless of pre-existing damage at the baseline investigation. In one case the arthrotic changes were progressive in nature. The person who had given up running presented with severe deterioration of the internal structures of the knee joint. CONCLUSION: Non-physiological maximal loads secondary to the marathon race do not cause any permanent damage in the internal structures of the knee joint in individuals without significant pre-existing damage. A disposition for premature arthrosis was not registered in the population investigated. A protective value of long distance running on the internal structures of the knee joint is discussed.
参考中文摘要:
目的:研究以评估长期损害的内部结构膝关节娱乐长跑运动员。材料与方法: 10年后他们参与基线研究关于其膝关节,七长跑运动员和1名谁放弃了长跑应邀参加了重复磁共振成像( MRI )的调查。同样的评价标准和相同的技术设备,使用,结果两次调查进行比较。结果:无不利的长期后果观察6 7积极选手,不论原已存在的损害的基线调查。在一个案件中, arthrotic变化,进步的性质。谁的人已放弃了与运行提出了严重恶化的内部结构膝关节。结论:非生理最大负荷中学的马拉松比赛不会造成任何永久性损伤的内部结构膝关节在个人没有重大预先存在的损害。处分早产关节没有登记的人口调查。防护价值长跑的内部结构膝关节进行了讨论。
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5
参考中文标题:
流行病理结果无症状膝盖的马拉松选手之前和之后的竞争相比,身体的活动主题, 3.0 Ť磁共振成像研究。
PMID及链接:
18463868 http://www.syyxw.com/Archive/Detail/18463868
摘 要:
PURPOSE: To determine the prevalence of pathologic findings in asymptomatic knees of marathon runners before and after a competition in comparison with physically active subjects. To compare the diagnostic performance of cartilage-dedicated magnetic resonance imaging (MRI) sequences at 3.0 T. MATERIALS AND METHODS: Ten marathon runners underwent 3.0 T MRI 2-3 days before and after competition. Twelve physically active asymptomatic subjects not performing long-distance running were examined as controls. Pathologic condition was assessed with the whole-organ magnetic resonance imaging score (WORMS). Cartilage abnormalities and bone marrow edema pattern (BMEP) were quantified. Visualization of cartilage pathology was assessed with intermediate-weighted fast spin-echo (IM-w FSE), fast imaging employing steady-state acquisition (FIESTA) and T1-weighted three-dimensional (3D) high-spatial-resolution volumetric fat-suppressed spoiled gradient-echo (SPGR) MRI sequences. RESULTS: Eight of ten marathon runners and 7/12 controls showed knee abnormality. Slightly more and larger cartilage abnormalities, and BMEP, in marathon runners yielded higher but not significantly different WORMS (P > 0.05) than in controls. Running a single marathon did not alter MR findings substantially. Cartilage abnormalities were best visualized with IM-w FSE images (P < 0.05). CONCLUSION: A high prevalence of knee abnormalities was found in marathon runners and also in active subjects participating in other recreational sports. IM-w FSE sequences delineated more cartilage MR imaging abnormalities than did FIESTA and SPGR sequences.
参考中文摘要:
目的:确定的流行病理结果无症状膝盖的马拉松选手之前和之后的竞争相比,身体的活动主题。比较诊断性能的软骨专用磁共振成像( MRI )序列为3.0吨材料与方法: 10名马拉松运动员进行3.0 Ť磁共振2-3天之前和之后的竞争。 12个科目的体力活动,无症状不理想长跑检查对照。病理状态的评估与整个器官磁共振成像评分(蠕虫) 。软骨畸形和骨髓水肿模式( BMEP )的量化。可视化软骨病理学评估中间加权快速自旋回波(即时通讯钨法兰克福) ,快速成像采用稳态采集(嘉年华)和T1加权三个三维( 3D )高空间分辨率的体积脂肪抑制破坏性梯度回波(梯度回波同)磁共振成像序列。结果:有8个10马拉松选手和7月12日控制显示膝关节畸形。稍微大软骨异常, BMEP ,在马拉松运动员取得较高,但无显着差异蠕虫( P “ 0.05 )比对照。运行一个单一的马拉松比赛并没有改变的MR表现大大。软骨异常最佳可视化与通讯钨序列图像( P “ 0.05 ) 。结论:高患病率膝关节畸形中发现马拉松选手,还积极参加其他科目休闲运动。即时通讯钨自旋回波序列划定更多的软骨磁共振成像异常比Fiesta和梯度回波同序列。
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6
参考中文标题:
软骨厚度的比较级与放射治疗膝关节骨性关节炎。
PMID及链接:
18461323 http://www.syyxw.com/Archive/Detail/18461323
摘 要:
OBJECTIVE: To compare joint space width (JSW) measurements obtained from magnetic resonance imaging (MRI) with a semi-automated computer algorithm to the Kellgren and Lawrence grading of osteoarthritis (OA). MATERIALS AND METHODS: Three hundred and six patients (234 female, 72 male) with a mean age of 56.7 years (range 31-81 years) underwent MRI of their knees with a fast oblique spiral spoiled gradient (SPGR) sequence. A board-certified musculoskeletal radiologist graded the OA of all the patients in accordance with the Kellgren and Lawrence OA scale. A previously validated computer algorithm was used to determine the minimum JSW for both the tibiofemoral joint and the patellofemoral joint. An analysis of variance (ANOVA) with the Student-Newman-Kuels post-hoc test was used to determine if there were differences in JSW as a function of OA grade. RESULTS: The radiologic grade of OA was inversely associated with the JSW. In the medial compartment the JSW did not change significantly between grade 1 and grade 2, but there was a significant decrease in JSW between grade 0 (normal) and grade 1 and for each OA grade above grade 2. In the lateral compartment no statistical differences were found till grade 2, while grade 3 was found to be statistically different from the previous one. The number of patients with a grade 4 patellofemoral OA was too low for the statistical significance to be assessed. In the patellofemoral joint the JSW did not change significantly until grade 2, while a statistically significant reduction was found for both grade 3 and grade 4. CONCLUSION: This study showed that an inverse non-linear relationship exists between radiologic grade and JSW. The relationship differs for the tibiofemoral and the patellofemoral joint.
参考中文摘要:
目的:比较联合空间宽度( JSW )测量获得磁共振成像( MRI ) ,以半自动化的计算机算法Kellgren和劳伦斯分级骨关节炎( OA ) 。材料与方法: 300名和6名患者( 234女, 72岁的男性) ,平均年龄为56.7岁(范围31-81岁)接受了核磁共振的膝盖与快速斜螺旋破坏梯度(梯度回波同)序列。董事会认证肌肉骨骼放射渐变的办公自动化系统的所有患者根据Kellgren和劳伦斯办公规模。一个先前验证计算机算法来确定最低JSW都胫股关节和髌股关节。方差分析(方差分析)与学生两Kuels事后测试是用来确定是否有差异JSW作为一个功能的OA级。结果: X线级的OA是成反比与JSW 。内侧隔的JSW没有明显改变的1级和2级,但有一个显着减少, JSW之间0级(正常)和1级和每个办公级以上2级。在横向舱室无统计学差异,到2级, 3级时,发现在统计不同于以往的一个。的病人数目与四级髌股关节炎太低的统计学上的意义进行评估。在髌股关节的JSW没有明显改变,直到2级,而统计学显着减少被发现为3级和4级。结论:本研究表明,反非线性关系存在放射级和JSW 。不同的关系的胫股及髌股关节。
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7
参考中文标题:
协会的外围垂直半月板眼泪与前十字韧带眼泪。
PMID及链接:
18463866 http://www.syyxw.com/Archive/Detail/18463866
摘 要:
OBJECTIVE: The purpose of this article is to describe a type of meniscal tear seen on magnetic resonance (MR) imaging, the peripheral vertical tear, and to determine the prevalence of anterior cruciate ligament (ACL) tears in knees with this type of meniscal tear compared to knees with other types of meniscal tears. MATERIALS AND METHODS: Following Institutional Review Board approval, a retrospective review of 200 knee MR examinations with imaging diagnoses of 'meniscal tear' was performed to assess the location and morphology of the meniscal tear, and to assess the status of the ACL. RESULTS: Nineteen peripheral vertical meniscal tears were identified in 17 patients, 14 of whom had acute ACL tears, prior ACL reconstruction, or chronic ACL deficiency. Three peripheral vertical tears were seen in the setting of a normal ACL. Of the 183 examinations with other types of meniscal tears, there were 17 cases with acute ACL tears, prior ACL reconstruction, or chronic ACL deficiency. The difference in the prevalence of ACL tear, reconstruction, or deficiency in knees with meniscal tears of the peripheral vertical type (82.4%) compared with the prevalence of ACL tear, reconstruction, or deficiency in knees with other types of meniscal tears (9.3%) was statistically significant (P < 0.001). The calculated specificity of the presence of peripheral vertical tear morphology in detecting an ACL injury in patients with meniscal tears was 98.2%. CONCLUSIONS: Peripheral vertical meniscal tears, particularly when involving the posterior horn, are highly associated with ACL tear, deficiency, or reconstruction. The finding of this type of tear on knee MR imaging should prompt close inspection of the ACL for evidence of acute or chronic injury, and its presence may help make the diagnosis of ACL tear in equivocal cases.
参考中文摘要:
目的:本文描述了一种半月板撕裂上看到磁共振(先生)成像,周边纵向撕裂,并确定患病前交叉韧带( ACL )含泪跪下这种类型的半月板撕裂相比与其他类型的膝盖半月板眼泪。材料与方法:以下机构审查委员会的批准,回顾性分析200膝关节磁共振成像检查与诊断,半月板撕裂'进行评估的位置和形态的半月板撕裂,并评估地位的ACL 。结果: 19个半月板周围垂直眼泪中发现17例,其中14人已经急性的ACL眼泪,事先的ACL重建,或慢性的ACL缺陷。三个外围垂直眼泪被视为在建立一个正常的ACL 。 183考试与其他类型的半月板的眼泪,有17例急性前交叉韧带的眼泪,事先的ACL重建,或慢性的ACL缺陷。差异普遍存在的韧带撕裂,重建,或缺乏膝关节半月板撕裂的外围垂直型( 82.4 % )比较普遍存在的韧带撕裂,重建,或缺乏症与其他类型的膝盖半月板的眼泪( 9.3 % )有统计学意义( P “ 0.001 ) 。计算特异性的存在形态周边纵向撕裂检测的ACL损伤的患者半月板眼泪为98.2 % 。结论:半月板周围垂直眼泪,特别是当涉及到后角,是高度相关的韧带撕裂,缺乏症,或重建。发现这种类型的撕裂膝关节磁共振成像应及时密切检查的ACL证据急性或慢性损伤,它的存在可帮助诊断韧带撕裂,模棱两可的案件。
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8
参考中文标题:
膝关节脱位:一个磁共振成像研究与临床和手术结果。
PMID及链接:
18463869 http://www.syyxw.com/Archive/Detail/18463869
摘 要:
OBJECTIVES: Our objectives were to determine retrospectively the prevalence, patients' demographics, mechanism of injury, combination of torn ligaments, associated intra-articular and extra-articular injuries, fractures, bone bruises, femoral-tibial alignment and neurovascular complications of knee dislocations as evaluated by magnetic resonance (MR) imaging. MATERIALS AND METHODS: From 17,698 consecutive knee examinations by magnetic resonance imaging (MRI) over a 6-year period, 20 patients with knee dislocations were identified. The medical records of these patients were subsequently reviewed for relevant clinical history, management and operative findings. RESULTS: The prevalence of knee dislocations was 0.11% [95% confidence interval (95% CI) 0.06-0.16)]. There were 16 male patients and four female patients, with ages ranging from 15 years to 76 years (mean 31 years). Fifteen patients had low-velocity injuries (75%), of which 11 were amateur sports related and four were from falls. Four patients (20%) had suffered high-velocity trauma (motor vehicle accidents). One patient had no history available. Anatomic alignment was present at imaging in 16 patients (80%). Eighteen patients had three-ligament tears, two had four-ligament tears. The four-ligament tears occurred with low-velocity injuries. The anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) were torn in every patient; the lateral collateral ligament (LCL) was torn in 50%, and the medial collateral ligament (MCL) in 60%. Intra-articular injuries included meniscal tears (five in four patients), fractures (eight in seven patients), bone bruises (15 patients), and patellar retinaculum tears (eight partial, two complete). The most common extra-articular injury was a complete biceps femoris tendon tear (five, 25%). There were two popliteal tendon tears and one iliotibial band tear. One patient had received a vascular injury following a motor vehicle accident (MVA) and had been treated prior to undergoing MRI. Bone bruises (unrelated to fractures), four-ligament tears, biceps femoris tears, and popliteus tendon tears were encountered only in the low-velocity knee dislocations. Twelve were treated surgically, five conservatively, and three had been lost to follow-up. The biceps femoris tendon was repaired in every patient who was treated surgically. CONCLUSIONS: Knee dislocations occurred more commonly in low-velocity injuries than in high-velocity injuries, predominantly affecting amateur athletes. Biceps femoris tendon tears were the most common extra-articular injury requiring surgery. Neurovascular injury (5%) was uncommon. At imaging, femoral-tibial alignment was anatomic in the majority of patients.
参考中文摘要:
目标:我们的目标是确定追溯的流行情况,病人的人口统计,机制的损伤,韧带撕裂的组合,相关关节内和关节外损伤,骨折,骨跌打损伤,股骨,胫骨神经并发症调整和膝关节脱位的评价磁共振(先生)成像。材料与方法:从17698连续膝检查磁共振成像( MRI )在6年期间, 20例膝关节脱位人已查明身份。医疗记录这些病人后来审查有关临床历史,管理和执行结果。结果:膝关节脱位是0.11 % [ 95 %置信区间( 95 % CI )的0.06-0.16 ) ] 。有16个男性和4名女病人,年龄从15岁到76岁(平均31岁) 。 15例有低速受伤( 75 % ) ,其中11名业余体育有关, 4人从瀑布。 4例( 20 % )遭受高速创伤(车祸) 。其中一名病人并没有历史上可用。解剖对齐出席成像在16例( 80 % ) 。 18例有三个,韧带眼泪,两人四韧带眼泪。四韧带眼泪发生低速受伤。前交叉韧带( ACL )和后交叉韧带(韧带)被推倒在每一个病人的外侧副韧带(柜)被拆除的50 % ,内侧副韧带( MCL洲立)的60 % 。关节内半月板受伤列入眼泪( 5 4例) ,骨折( 8例) ,骨淤伤( 15例) ,并带眼泪(八部分,两个完整的) 。最常见的关节外损伤是一个完整的股二头肌肌腱撕裂( 5 , 25 % ) 。有两个腘肌腱的眼泪和一个髂胫带撕裂。 1例患者接受了血管损伤后,机动车辆事故(增值) ,并已接受治疗之前, MRI检查。骨瘀伤(无关的骨折) , 4韧带眼泪,股二头肌的眼泪,和眼泪popliteus肌腱遇到了只有在低速膝关节脱位。其中12人是手术治疗, 5个保守,三个失去了后续行动。在股二头肌肌腱修复中的每一位病人谁是手术治疗。结论:膝关节脱位发生较为普遍的低速伤害比高速受伤,主要是影响到业余运动员。股二头肌肌腱眼泪是最常见的关节外损伤,需要手术治疗。神经损伤( 5 % )是罕见的。在成像,股骨,胫骨解剖定位是在大多数病人。
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参考中文标题:
关节结节性筋膜炎的肩关节联合。
PMID及链接:
18324399 http://www.syyxw.com/Archive/Detail/18324399
摘 要:
We describe a case of multiple intra-articular masses in the glenohumeral joint of a 15-year-old patient. The patient was treated with arthroscopic excision of the masses and synovectomy. Histological and immunohistochemical studies were consistent with those of a nodular fasciitis. Follow-up examination did not reveal recurrence at 6 months. In this article we report the first case of articular nodular fasciitis in the glenohumeral joint with unusual imaging findings.
参考中文摘要:
我们描述一个案件多个关节内群众肩关节联合了15岁的病人。病人治疗关节镜切除滑膜切除群众。组织学及免疫组织化学研究,符合这些的结节性筋膜炎。后续检查没有发现复发的6个月。在本文中我们报告首例关节结节性筋膜炎的盂关节异常影像学表现。
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腱鞘巨细胞瘤的后弓的C1 。
PMID及链接:
18309482 http://www.syyxw.com/Archive/Detail/18309482
摘 要:
Tenosynovial giant cell tumor, also called pigmented villonodular synovitis, is a disease typically of the joints and which uncommonly involves the spine. We present a case of a mass of the posterior C1 arch which eroded bone and did not arise from the facet joint. The imaging findings of spinal tenosynovial giant cell tumor will be reviewed as well as the imaging findings in this case, where tenosynovial giant cell tumor arose presumably within a small bursa. One's understanding of the imaging characteristics can lead to the correct diagnosis and avoid an unnecessary work-up.
参考中文摘要:
腱鞘巨细胞瘤,也称为色素绒毛结节性滑膜炎,是一种疾病通常关节及其中包括脊椎异常。我们提出一个案件的质量后的C1拱的侵蚀骨,并没有引起关节。成像结果脊髓腱鞘巨细胞瘤会作出检讨,以及影像学表现在这种情况下,在腱鞘巨细胞瘤发生大概在一个小囊。一个人的理解,影像学特征可能导致正确的诊断,避免不必要的工作行动。
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侵袭性血管粘液瘤的大腿。
PMID及链接:
18338163 http://www.syyxw.com/Archive/Detail/18338163
摘 要:
Aggressive angiomyxoma is a rare tumour that typically occurs in the perineum in women of reproductive age. A small number of cases occurring in men have been reported, all of which were located in the low pelvis, perineum or scrotum. While benign, the tumour is locally infiltrative and consequently has a high rate of local recurrence following surgery; therefore, accurate pre-operative diagnosis is important. The characteristic location of these tumours in the low pelvis or perineum has led to speculation that aggressive angiomyxomas arise from a mesenchymal cell that is unique to the perineum. We describe a case of aggressive angiomyxoma arising in the thigh of a 54-year-old man, which we believe is the first reported instance of this rare neoplasm occurring remote from the pelvis or perineum in a male patient. Cross-sectional imaging demonstrated a well-defined mass that had low density on CT and high intensity on fluid-sensitive MR sequences. Biopsy was non-diagnostic and excision was performed. At histological analysis, the tumour exhibited the characteristic features of aggressive angiomyxoma, with bland spindle cells and large, hyalinised blood vessels in a hypocellular myxoid matrix. Extensive immunohistochemical staining further supported the diagnosis. While the imaging features of these tumours are non-specific and suggestive of myxoid neoplasms, the diagnosis should be considered whenever biopsy of a myxoid-appearing mass yields hypocellular, non-diagnostic material, despite adequate sampling.
参考中文摘要:
侵袭性血管粘液瘤是一种罕见的肿瘤,通常发生在会阴部的育龄妇女。少数病例发生在男性的报告,所有这些都是位于低骨盆,会阴或阴囊。虽然良性,肿瘤局部浸润,因此具有较高的局部复发率的手术后,因此,准确的术前诊断是非常重要的。位置的特点,这些肿瘤在低骨盆或会阴部,导致猜测,积极angiomyxomas源于间充质细胞所独有的阴部。我们描述一个案件中出现的侵袭性血管粘液瘤的大腿的54岁男子,我们相信这是首次报告的实例发生这种罕见肿瘤远离骨盆或会阴部的男性病人。横断面成像表现出明确的质量有低密度的CT和高强度的流体敏感磁共振序列。活检非诊断和手术切除手术。在组织学分析,肿瘤的特征表现的侵袭性血管粘液瘤,梭形细胞与乏味和大型, hyalinised血管在hypocellular粘液样基质。广泛的免疫组织化学染色法进一步支持诊断。虽然影像学特征这些肿瘤的非特异性和暗示黏液肿瘤,诊断时,应考虑活检的黏液,出现大规模产量hypocellular ,非诊断材料,尽管适当的采样。
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12
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丙型肝炎相关的骨硬化:一病例报告。
PMID及链接:
18414851 http://www.syyxw.com/Archive/Detail/18414851
摘 要:
A 38-year-old man presented for evaluation of severe pain in his lower limbs of 16 months' duration. Radiographs showed diffuse bony sclerosis involving the axial and appendicular skeleton with marked cortical thickening in the diaphyseal regions of the long bones. Iliac crest biopsy revealed abundant sclerotic bone. The patient was diagnosed with hepatitis C secondary to intravenous drug use 20 years earlier, and the bony findings and clinical symptoms attributed to hepatitis C-associated osteosclerosis (HCAO). Little is known about the natural history of this disease; however, we discuss the patient's clinical course over 15 years.
参考中文摘要:
一名38岁男子提出评价剧烈疼痛在他的下肢16个月的时间。 X光片显示弥漫性骨质硬化涉及的轴向和四肢骨骼有明显的皮质增厚骨干区域的长骨。髂嵴活检发现丰富的硬化骨。病人被诊断患有丙型肝炎继发静脉注射毒品使用20年前,和骨骼的调查结果和临床症状归因于C型肝炎相关的骨硬化( HCAO ) 。知之甚少的自然历史的这种疾病,但是,我们讨论了病人的临床病程超过15年。
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参考中文标题:
原发性横纹肌肉瘤的骶骨:病例报告及文献复习。
PMID及链接:
18421456 http://www.syyxw.com/Archive/Detail/18421456
摘 要:
We describe herein a rare case of primary rhabdomyosarcoma (RMS) occurring in the sacrum. A 16-year-old woman presented with a 2-month history of pain in bilateral buttocks and posterior thighs. Computed tomography showed a primary tumor with bone destruction in the 2nd sacral vertebra and invasion to the 1st to 3rd vertebrae and retroperitoneal space. Histological examination of the tumor showed proliferation of spindle-shaped cells intermingled with rhabdomyoblasts in a fascicular and storiform growth pattern. Tumor cells showed immunoreactivity for vimentin, desmin, muscle-specific actin, sarcomeric actin, alpha-smooth muscle actin and CD99, and partial immunoreactivity for myoD1, myf-4, myogenin and myoglobin. Reverse transcription polymerase chain reaction demonstrated expression of myoD1. On the basis of the aforementioned findings, a poorly differentiated spindle cell variant of embryonal RMS was diagnosed. The patient underwent combined therapy with chemotherapy and radiotherapy, but died 17 months after incisional biopsy. The present case is instructive in differential diagnosis of primary bone tumors, and the possibility of skeletal RMS needs to be considered.
参考中文摘要:
我们描述此一例罕见的原发性横纹肌肉瘤( RMS )运用发生在骶骨。一名16岁女子,有一个2个月的痛苦历史的双边臀部和大腿后部。计算机断层扫描显示,原发肿瘤与骨破坏在第二骶椎和入侵的第1至第3腰椎和腹膜后间隙。组织学检查显示,肿瘤扩散的梭形细胞混杂在同rhabdomyoblasts束和storiform增长模式。肿瘤细胞免疫反应的波形蛋白,结蛋白,肌特异性肌动蛋白,肌动蛋白, α -平滑肌肌动蛋白和CD99 ,和部分免疫活性的myoD1 , myf - 4 ,肌细胞生成素和肌红蛋白。逆转录聚合酶链反应表明表达myoD1 。根据上述调查结果,低分化梭形细胞变异的胚胎有效值被诊断。病人接受联合治疗化疗和放疗,但去世后17个月切口活检。目前的情况是有启发性的鉴别诊断原发性骨肿瘤,并有可能骨骼肌有效值需要考虑。
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